DNA Research
Researchers from Brussels Free University detail findings in DNA research
Published in Proteomics Weekly, November 2nd, 2009
According to recent research from Brussels, Belgium, "Locked nucleic acids (LNA), conformationally restricted nucleotide analogues, are known to enhance pairing stability and selectivity toward complementary strands. With the aim to contribute to a better understanding of the origin of these effects, the structure, thermal stability, hybridization thermodynamics, and base-pair dynamics of a full-LNA:DNA heteroduplex and of its isosequential DNA:DNA homoduplex were monitored and compared."
"CD measurements highlight differences in the duplex structures: the homoduplex and heteroduplex present B-type and A-type helical conformations, respectively. The pairing of the...
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Source: Proteomics Weekly (2009-11-02)
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