DNA Research

Researchers from University of Calgary discuss findings in DNA research

Published in Proteomics Weekly, November 2nd, 2009

According to a study from Calgary, Canada, "Singlet oxygen is known to be a potent mutagenic agent and several biologically relevant molecules have been proposed to act as scavengers for this noxious species. However, numerous studies have been conducted in homogenous solution and the reactivity of singlet oxygen scavengers known to bind DNA has never been investigated in double-stranded DNA."

"In the following paper, we present the results obtained regarding the interaction between 4',6-diamidino-2-phenylindole (DAPI) and singlet oxygen. We show the molecule to be a potent scavenger of singlet oxygen in aqueous solution with an absolute rate constant (chemical and...

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Source: Proteomics Weekly (2009-11-02)

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