Adenovirus

Reports from Kanazawa University describe recent advances in adenovirus

Published in Proteomics Weekly, November 2nd, 2009

"Drug-induced hepatotoxicity is a major problem in drug development, and oxidative stress is known as one of the causes. Superoxide dismutases (SODs) are important antioxidant enzymes against reactive oxygen species (ROS)," researchers in Kanazawa, Japan report.

"Mitochondria are the major source of superoxide production, and SOD2 is mainly localized in mitochondria and, with other SODs, plays an important role in scavenging superoxide. In this study, we established SOD2-knockdown cells. An adenovirus vector with short hairpin RNA against rat SOD2 (AdSOD2-shRNA) was constructed, and infection of AdSOD2-shRNA to rat hepatic BRL3A cells resulted in significant decreases...

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Source: Proteomics Weekly (2009-11-02)

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