Fusion Proteins

Study data from H.J. Metzner et al provide new insights into fusion proteins

Published in Proteomics Weekly, November 30th, 2009

According to recent research published in the journal Thrombosis and Haemostasis, "Haemophilia B is a X-chromosome linked disease characterised by a deficiency of functionally active coagulation Factor IX (FIX). with severe haemophilia B at risk of recurrent bleeding are treated approximately twice a week in a prophylactic setting by application of FIX concentrates."

"To increase convenience and compliance of the therapy it is desirable to reduce the dosing frequency by improving the pharmacokinetic properties of FIX. Here a concept of rFIX (recombinant factor IX) albumin fusion proteins (rIX-FPs) with cleavable linker peptides derived from the FIX activation...

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Source: Proteomics Weekly (2009-11-30)

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