Enzyme Research

Reports summarize enzyme research research from L. Lartigue and co-authors

Published in Proteomics Weekly, February 1st, 2010

"In apoptosis, mitochondrial outer membrane permeabilization (MOMP) triggers caspase-dependent death. However, cells undergo clonogenic death even if caspases are blocked," scientists writing in the journal Molecular Biology of the Cell report.

"One proposed mechanism involved the release of cytotoxic proteins (e.g., AIF and endoG) from mitochondria. To initiate MOMP directly without side effects, we created a tamoxifen-switchable BimS fusion protein. Surprisingly, even after MOMP, caspase-inhibited cells replicated DNA and divided for similar to 48 h before undergoing proliferation arrest. AIF and endoG remained in mitochondria. However, cells gradually lost...

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Source: Proteomics Weekly (2010-02-01)

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