Published in Proteomics Weekly, February 1st, 2010
"One proposed mechanism involved the release of cytotoxic proteins (e.g., AIF and endoG) from mitochondria. To initiate MOMP directly without side effects, we created a tamoxifen-switchable BimS fusion protein. Surprisingly, even after MOMP, caspase-inhibited cells replicated DNA and divided for similar to 48 h before undergoing proliferation arrest. AIF and endoG remained in mitochondria. However, cells gradually lost...
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