Proteomics
Research results from Tohoku University update knowledge of proteomics
Published in Proteomics Weekly, February 1st, 2010
"(2S)-2-Fmoc-amino-3-(5'-deoxyuridinylamino)-3-oxopropyloxyacetic acid was synthesized from L-serine as a monomer for preparing the second-generation peptide ribonucleic acid with an oxa-peptide backbone (oxa-PRNA). The ether linkage was incorporated to improve the modest solubility in aqueous solution of the original PRNA with an iso-glutamine backbone, without harming the ability of the aminouridine side chain to switch the anti/syn nucleobase orientation by adding borax," investigators in Sendai, Japan report.
"Indeed, CD spectral examinations revealed that the Fmoc-protected oxa-PRNA uridine monomer (Fmoc-oxa-PRNA(U)), synthesized in three steps, switched the...
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Source: Proteomics Weekly (2010-02-01)
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