Fusion Proteins

Research on fusion proteins described by J.L. Fast and colleagues

Published in Proteomics Weekly, February 1st, 2010

According to a study from Basel, Switzerland, "Protein therapeutics made up of artificially combined proteins or protein domains, so-called fusion proteins, are a novel and growing class of biopharmaceuticals. We have studied abatacept (Orencia), a fusion protein that is constructed of a modified IgG Fe domain and the soluble part of the T-cell receptor CTLA-4."

"In accelerated degradation studies conducted at 40 degrees C, a pH shift from 7.5 to 6.0 yields significantly faster aggregation kinetics, as measured by size-exclusion chromatography. To understand how the fusion domains and their interactions contribute to this result, we considered aggregation in light of...

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Source: Proteomics Weekly (2010-02-01)

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