Enzyme Research

Researchers from Institute Pasteur describe findings in enzyme research

Published in Proteomics Weekly, February 1st, 2010

Fresh data on enzyme research are presented in the report 'Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.' "Senescence is an irreversible cell-cycle arrest that is elicited by a wide range of factors, including replicative exhaustion. Emerging evidences suggest that cellular senescence contributes to aging and acts as a tumor suppressor mechanism," scientists in Lille, France report.

"To identify novel genes regulating senescence, we performed a loss-of-function screen on normal human diploid fibroblasts. We show that downregulation of the AMPK-related protein kinase 5 (ARK5 or NUAK1) results in extension of the cellular replicative lifespan....

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Source: Proteomics Weekly (2010-02-01)

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