Escherichia coli
New Escherichia coli study findings have been reported by scientists at Cornell University
Published in Proteomics Weekly, February 15th, 2010
According to a study from the United States, "Recombinant expression of eukaryotic proteins in Escherichia coli is often limited by poor folding and solubility. To address this problem, we employed a recently developed genetic selection for protein folding and solubility based on the bacterial twin-arginine translocation (Tat) pathway to rapidly identify property folded recombinant proteins or soluble protein domains of mammalian origin."
"The coding sequences for 29 different mammalian polypeptides were cloned as sandwich fusions between an N-terminal Tat export signal and a C-terminal selectable marker, namely beta-lactamase. Hence, expression of the selectable marker...
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Source: Proteomics Weekly (2010-02-15)
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