Cancer Vaccines

Researchers at National Autonomous University have published new data on cancer vaccines

Published in Proteomics Weekly, February 22nd, 2010

"While the antigenic variability is the major obstacle for developing vaccines against antigenically variable pathogens (AVPs) and cancer, this issue is not addressed adequately in current vaccine efforts. We developed a novel variable epitope library (VEL)-based vaccine strategy using immunogens carrying a mixture of thousands of variants of a single epitope," investigators in Mexico report.

"In this proof-of-concept study, we used an immunodominant HIV-1-derived CD8+ cytotoxic T-lymphocyte (CTL) epitope as a model antigen to construct immunogens in the form of plasmid DNA and recombinant M13 bacteriophages. We generated combinatorial libraries expressing epitope...

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Source: Proteomics Weekly (2010-02-22)

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