Cardiology
New cardiology study findings recently were reported by researchers at China Medical University
Published in Proteomics Weekly, February 22nd, 2010
"In this study, we investigated the roles of calmodulin kinase II (CaMKII) and calmodulin (CaM) in the reversal of run-down of L-type Ca2+ channels. Single Ca2+-channel activities in guinea-pig ventricular myocytes were recorded using the patch-clamp technique, and run-down of the channel activities was induced by inside-out patch formation in the basic internal solution," scientists in Shenyang, People's Republic of China report.
"At 1 min after patch excision, 1-30 mc M CaMKII mutant T286D (CaMKIIT286D), a constitutively active type of CaMKII, induced the Ca2+-channel activities to only 2%-10% of that recorded in the cell-attached mode. However, in the presence of...
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Source: Proteomics Weekly (2010-02-22)
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