Published in Proteomics Weekly, February 22nd, 2010
"However, the mechanism of action by which chronic sildenafil exerts its effects on reactive oxygen species sources is still largely unknown. We therefore investigated how chronic sildenafil administration could impact vascular endothelial NO and superoxide release in a rat model of insulin resistance induced by fructose overload. Adult male Wistar rats were fed a fructose-enriched diet (fructose-fed rats [FFR]) for 9 weeks. From weeks 6-8, sildenafil was administered...
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