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Antiretrovirals

Findings from Boston University provide new insights into antiretrovirals

Published in Proteomics Weekly, June 7th, 2010

Scientists discuss in 'Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir' new findings in antiretrovirals. According to a study from the United States, "The advent of HIV protease inhibitors has greatly extended the life span of AIDS patients. With an aging HIV(+) population, the cardiometabolic side effects of these drugs are becoming increasingly important clinical concerns."

"The purpose of this study was to test the hypothesis that inhibition of adipose lipolysis will retard atherogenic lesion development induced by the antiviral protease inhibitors. LDLR-null mice receiving ritonavir were...

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