Phosphoric Monoester Hydrolases
Research from University of Toronto has provided new information about phosphoric monoester hydrolases
Published in Proteomics Weekly, August 2nd, 2010
Fresh data on phosphoric monoester hydrolases are presented in the report 'Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression.' "Interleukin-1 (IL-1) induces extracellular matrix degradation as a result of increased expression of matrix metalloproteinases (MMPs). We examined adhesion-restricted signaling pathways that enable IL-1-induced MMP release in human gingival and murine fibroblasts," researchers in Toronto, Canada report.
"Of the seven MMPs and three tissue inhibitors of MMPs screened, IL-1 enhanced release only of MMP3 when cells formed focal adhesions....
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Source: Proteomics Weekly (2010-08-02)
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