Molecular Imaging
New Research on Molecular Imaging from Kyoto University Summarized
Published in Proteomics Weekly, October 31st, 2011
2011 OCT 31 -- "We aimed to evaluate the feasibility of using streptavidin-biotin-based pretargeting for positron emission tomography (PET) imaging of hypoxia-inducible factor (HIF)-1-active tumors. We used POS, a genetically engineered form of streptavidin that selectively stabilizes in HIF-1-active cells, and (4-F-18-fluorobenzoyl)norbiotinamide (F-18-FBB), a radiolabeled biotin derivative, for performing a biodistribution study and for PET imaging," researchers in Kyoto, Japan report.
"The tumoral F-18-FBB accumulation was compared to the HIF-1-dependent luciferase bioluminescence and HIF-1 alpha immunohistochemical signal. F-18-FBB accumulation was...
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Source: Proteomics Weekly (2011-10-31)
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