Aromatic Amino Acids

Data on Aromatic Amino Acids Reported by Researchers at University of Wurzburg

Published in Proteomics Weekly, October 31st, 2011

2011 OCT 31 -- According to the authors of a study from Wurzburg, Germany, "Alternative intronic polyadenylation (IPA) can generate truncated protein isoforms with significantly altered functions. Here, we describe 31 dominant-negative, secreted variant isoforms of receptor tyrosine kinases (RTKs) that are produced by activation of intronic poly(A) sites."

"We show that blocking U1-snRNP can activate IPA, indicating a larger role for U1-snRNP in RNA surveillance. Moreover, we report the development of an antisense-based method to effectively and specifically activate expression of individual soluble decoy RTKs (sdRTKs) to alter signaling, with potential...

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Source: Proteomics Weekly (2011-10-31)

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