Phosphotransferases (Alcohol Group Acceptor)

Investigators at Hannover School of Medicine Have Published New Data on Phosphotransferases (Alcohol Group Acceptor)

Published in Proteomics Weekly, October 31st, 2011

2011 OCT 31 -- According to the authors of a study from Hannover, Germany, "The transcription factor FOXM1c possesses a very strong C-terminal TAD (transactivation domain), but full-length FOXM1c is only a weak transactivator because the TAD is completely inhibited by the auto-inhibitory N-terminus. The N-terminus blocks the TAD by directly binding to the TAD."

"Accordingly, FOXM1c deletion mutants without N-terminus are strong transactivators. Therefore, the question arises whether signals exist, which activate full-length FOXM1c by releasing the FOXM1c-TAD from its inhibition by the N-terminus. Indeed, full-length FOXM1c is strongly activated by protein...

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Source: Proteomics Weekly (2011-10-31)

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