RNA-Directed DNA Polymerase
New RNA-Directed DNA Polymerase Study Findings Have Been Reported by Researchers at McGill University
Published in Proteomics Weekly, February 27th, 2012
2012 FEB 27 -- "A rationally designed progression of phenanthroimidazole platinum(II) complexes were examined for their ability to target telomere-derived intramolecular G-quadruplex DNA. Through the use of circular dichroism, fluorescence displacement assays, and molecular modeling we show that these complexes template and stabilize G-quadruplexes from sequences based on the human telomeric repeat (TTAGGG)n," scientists in Montreal, Canada report.
"The greatest stabilization was observed for the p-chlorophenyl derivative 6 (G4DC50=0.31 mu M). We also show that the G-quadruplex binding complexes are able to inhibit telomerase activity through a modified...
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Source: Proteomics Weekly (2012-02-27)
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