DNA Research

Investigators at Emory University Detail Research in DNA Research

Published in Proteomics Weekly, February 27th, 2012

2012 FEB 27 -- According to the authors of recent research from Atlanta, Georgia, "Numerous studies have shown that ribonucleoside monophosphates (rNMPs) are probably abundant among all nonstandard nucleotides occurring in genomic DNA. Therefore, it is important to understand to what extent rNMPs may alter genome integrity and what factors affect their stability."

"We developed oligonucleotide-driven gene correction assays in Escherichia coli and Saccharomyces cerevisiae to show that mispaired rNMPs embedded into genomic DNA, if not removed, serve as templates for DNA synthesis and produce a genetic change. We discovered that isolated mispaired rNMPs in...

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Source: Proteomics Weekly (2012-02-27)

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