Molecular Cell Research

Data on Molecular Cell Research Detailed by Researchers at Technion-Israel Institute of Technology

Published in Proteomics Weekly, March 12th, 2012

2012 MAR 12 -- "The 26S proteasome is a chambered protease in which the majority of selective cellular protein degradation takes place. Throughout evolution, access of protein substrates to chambered proteases is restricted and depends on AAA-ATPases," scientists in Haifa, Israel report.

"Mechanical force generated through cycles of ATP binding and hydrolysis is used to unfold substrates, open the gated proteolytic chamber and translocate the substrate into the active proteases within the cavity. Six distinct AAA-ATPases (Rpt1-6) at the ring base of the 19S regulatory particle of the proteasome are responsible for these three functions while interacting...

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Source: Proteomics Weekly (2012-03-12)

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