Findings in Proteomics Reported from San Gallicano Dermatological Institute

2012 APR 16 -- Research findings, "Inhibition of Melanogenesis by the Pyridinyl Imidazole Class of Compounds: Possible Involvement of the Wnt/ß-Catenin Signaling Pathway," are discussed in a new report. According to the authors of a study from Rome, Italy, "While investigating the role of p38 MAPK in regulating melanogenesis, we found that pyridinyl imidazole inhibitors class compounds as well as the analog compound SB202474, which does not inhibit p38 MAPK, suppressed both a-MSH-induced melanogenesis and spontaneous melanin synthesis. In this study, we demonstrated that the inhibitory activity of the pyridinyl imidazoles correlates with inhibition of the canonical...

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