Airway Branching
Fgf10 for lung morphogenesis is uniform; distal heparan sulfate activate it
Published in Respiratory Therapeutics Week, November 10th, 2003
According to a study from the United States, "Fibroblast growth factor (Fgf) 10 is a critical regulator of bud formation during lung morphogenesis. Fgf10 is expressed in distal lung mesenchyme at sites of prospective budding from the earliest developmental stages and signals through its epithelial receptor Fgfr2b.
"Experiments in intact lung organ cultures demonstrate that Fgf10 is a chemotactic factor for distal, but not for proximal, epithelium. This differential response suggests the involvement of an...
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