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Chronic Obstructive Pulmonary Disease

Infliximab treatment study of patients with pulmonary disease is inconclusive

Published in Respiratory Therapeutics Week, October 3rd, 2005

Results of first study of infliximab treatment in patients with chronic obstructive pulmonary disease are inconclusive.

According to a study from Netherlands, "Tumor necrosis factor-alpha is believed to be important in the induction and maintenance of airway inflammation in chronic obstructive pulmonary disease. We aimed to evaluate the effect of the anti-tumor necrosis factor-a drug infliximab in patients with chronic obstructive pulmonary disease, with percentage of sputum neutrophils as the primary endpoint."

"We performed an exploratory single-center, double-blind, placebo-controlled, randomized, phase 2 trial in which 22 current smokers with...

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