Lung Cancer
Radiation therapy potentiated effective oncolytic viral therapy
Published in Respiratory Therapeutics Week, October 3rd, 2005
"Replication-competent oncolytic herpes simplex viruses with deletion of the gamma1 34.5 gene preferentially replicate in and kill malignant cells. The gamma1 34.5 gene codes for ICP 34.5, a protein that enhances viral replication, and is homologous to growth arrest and DNA damage protein 34 (GADD34), a radiation-inducible DNA repair gene," scientists writing in the journal Annals of Thoracic Surgery reported.
"We hypothesized that radiation therapy may potentiate efficacy of oncolytic viral therapy by upregulating...
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