Cystic Fibrosis

Common food preservative might provide treatment for cystic fibrosis

Published in Respiratory Therapeutics Week, February 20th, 2006

Researchers say they have discovered what might be the "Achilles' heel" of a dangerous organism that lives in the lungs of cystic fibrosis (CF) patients - a fatal flaw that leaves the organism vulnerable to destruction by a common food preservative.

The new study suggests that a mutation, known as mucA, in the bacterium Pseudomonas aeruginosa that grows within the deadly, lung-clogging mucous found in the airways of CF patients, also represents a fatal flaw that could help clear the characteristic "goop" from the lungs of patients with advanced disease. Researchers say the same genetic change that turns P. aeruginosa into a sticky, antibiotic-resistant...

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Source: Respiratory Therapeutics Week (2006-02-20)

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