Pulmonary Medicine
Pulmonary vascular remodeling declines in dominant negative transforming growth factor models
Published in Respiratory Therapeutics Week, March 27th, 2006
"The present study utilized a novel transgenic mouse model that expresses an inducible dominant negative mutation of the transforming growth factor (TGF)-beta type II receptor (DnTGF beta RII mouse) to test the hypothesis that TGF-beta signaling plays an important role in the pathogenesis of chronic hypoxia-induced increases in pulmonary arterial pressure and vascular and alveolar remodeling," scientists in the United States report.
"Nine- to 10-wk-old male DnTGF beta RII and control nontransgenic (NTG) mice were exposed to normobaric hypoxia (10%...
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