Allergies
Studies from RIKEN describe new findings in allergies
Published in Respiratory Therapeutics Week, November 23rd, 2009
According to a study from Suehiro, Japan, "NLR family, pyrin domain containing 3 (NLRP3), controls the activity of inflammatory caspase-1 by forming inflammasomes, which leads to cleavage of the procytokines IL-1 beta and IL-18. Recent studies have shown associations of human NLRP3 polymorphisms with susceptibility to various inflammatory diseases; however, the association with allergic diseases remains unclear."
"We sought to examine whether NLRP3 polymorphisms are associated with susceptibility to food allergy, food-induced anaphylaxis, and aspirin-induced asthma (AIA). We selected 15 tag single nucleotide polymorphisms (SNPs) of NLRP3 and conducted association...
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