Hypertension

Data on hypertension detailed by researchers at University Medical Center

Published in Respiratory Therapeutics Week, April 5th, 2010

"Bone morphogenetic protein receptor type 2 (BMPR2) gene mutations are a major risk factor for heritable pulmonary arterial hypertension (HPAH), an autosomal dominant fatal disease. We have previously shown that BMPR2 transcripts that contain premature termination codon (PTC) mutations are rapidly and nearly completely degraded through nonsense mediated decay (NMD)," scientists in the United States report.

"Here we report a unique PTC mutation (W13X) that did not behave in the predicted manner. We found that patient-derived cultured lymphocytes (CLs) contained readily detectable levels of the PTC-containing transcript. Further analysis suggested that this transcript...

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Source: Respiratory Therapeutics Week (2010-04-05)

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