Science Letter
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Science Letter
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Acute Myeloid Leukemia
Acute myeloid leukemia with complex aberrant karyotype profiled
July 12th, 2005
Researchers suggested acute myeloid leukemia (AML) with a complex aberrant karyotype is a unique disease. According to recent research from Germany, "AML with a complex aberrant karyotype is a distinct biological entity." "It is characterized by: (1) a sharp increase in incidence above age 50; (2) a characteristic pattern of chromosomal gain and, especially, loss, that is, of 5q14q33q35, and 17p13, translating into reduced expression of genes in these regions; (3) a unique gene expression pattern including up-regulation of genes involved in DNA repair; (4) a high incidence of TP53 deletions and/or mutations; and (5) an overall unfavorable prognosis,"...
Source: Science Letter (2005-07-12)
|
