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Aging
Tyrosine kinase receptor analyzed, discordant changes in aging revealed
July 12th, 2005
Recent research from the United States has clarified the discordant changes in cortical tyrosine kinase receptor C (TrkC) mRNA and protein during the human lifespan. "Neurotrophin-3 (NT-3) exerts its trophic effects in brain via (trkC) signaling. TrkC splice variants produce receptors with (full-length) and without (truncated) a tyrosine kinase domain. "The relative abundance of trkC isoforms and the anatomical localization of trkC in the human prefrontal cortex (PFC) in relationship to development and maturation are currently unknown," wrote S. Beltaifa and colleagues, U.S. National Institute of Mental Health. "We have examined...
Source: Science Letter (2005-07-12)
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