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Alcohol Use

Article discusses the mechanisms of alcohol's effect on cardiac mitochondria

"Apoptosis of myocytes is likely to contribute to a variety of heart conditions and could also be important in the development of alcoholic heart disease. A fundamental pathway to apoptosis is through mitochondrial membrane permeabilization and release of proapoptotic factors from the mitochondrial intermembrane space to the cytosol," scientists in the United States report.

G. Hajnoczky and colleagues of Thomas Jefferson University wrote, "The authors' results show that prolonged exposure of cultured cardiac cells to ethanol (35 mM for 48 hours) promotes Ca²⁺-induced...

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