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Allergy Medicine
Atopic asthma studied, increase in killer-specific secretory protein shown
July 12th, 2005
A study from Germany has documented an increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid (BALF) of allergen-challenged patients with atopic asthma. "Atopic asthma is linked to a T-helper type 2 dominated pathogenesis, but there is increasing evidence of Th1/Tc1-mediated processes in the etiopathology of asthma," wrote M. Kuepper and colleagues, University of Rostock Medical Clinic. "Killer-specific secretory protein of 37 kDa (Ksp37) is expressed in cytotoxic lymphocytes, selectively in the effector subsets of CD8± and CD4+ T lymphocytes and in CD16+/CD56(dim) natural killer cells and gamma/delta T cells....
Source: Science Letter (2005-07-12)
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