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Allergy Medicine
DNA vaccine suppresses Der p induced allergic responses in mice
July 12th, 2005
Vaccination with DNA encoding human T-cell epitopes suppresses Der p induced allergic responses in mice. According to a study from South Korea and the United States, "The apparent complexity of allergen-specific T-cell response in terms of epitope usage in humans is a potential barrier to peptide-based immunotherapy for allergy. A knowledge of cross-reacting T-cell epitopes of common allergens might have an impact on the development of vaccines for immunotherapy. We examined the efficiency of vaccinating with plasmid DNA coding only human T-cell epitopes on the suppression of allergic reactions in mice." "BALB/c mice that received an injection of...
Source: Science Letter (2005-07-12)
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