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Allergy Medicine
Mediated mast cell migration studied, autocrine/paracrine nature revealed
July 12th, 2005
Recent research from the United States has described that IgE- and IgE+Ag-mediated mast cell migration occurs in an autocrine/paracrine fashion. "Mast cells are the major effector cells for immediate hypersensitivity and chronic allergic reactions. These cells accumulate in mucosal tissues of allergic reactions, where immunoglobulin E (IgE) is produced locally. "Here we provide evidence that, in addition to antigen that can attract IgE-bound mast cells, the type of IgE molecules that efficiently activate mast cells can promote the migration of mast cells in the absence of antigen," wrote J. Kitaura and colleagues, La Jolla Institute of Allergy &...
Source: Science Letter (2005-07-12)
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