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Allergy and Immunology
Heat shock protein 70 propels gene-directed enzyme prodrug therapy
July 12th, 2005
Heat shock protein 70 propels gene-directed enzyme prodrug therapy. According to a study from England, "gene-directed enzyme prodrug therapy (GDEPT) is a promising approach to local management of cancer through targeted chemotherapy. Killing localized tumors by GDEPT in a manner that induces strong antitumor cellular immune responses might improve local management and allow benefit in disseminated cancer." "Here we evaluated the combination of nitroreductase (NTR)/CB1954 GDEPT with high-level expression of heat shock protein 70 (HSP70, a stress protein that can shuttle cytosolic peptides into antigen-presenting cells) for induction of antitumor...
Source: Science Letter (2005-07-12)
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