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Alzheimer Disease
PAR-4 regulates beta-secretase cleavage of Alzheimer amyloid precursor protein
July 12th, 2005
PAR-4 helps regulate beta-secretase cleavage of Alzheimer amyloid precursor protein. "Mounting evidence indicates that aberrant production and aggregation of amyloid beta-peptide (A beta)-(1-42) play a central role in the pathogenesis of Alzheimer disease (AD). "A beta is produced when amyloid precursor protein (APP) is cleaved by beta-and gamma-secretases at the N and C termini of the A beta domain, respectively," scientists in the United States report. "The beta-secretase is membrane-bound aspartyl protease, most commonly known as BACE1. Because BACE1 cleaves APP at the N terminus of the A beta domain, it catalyzes the first...
Source: Science Letter (2005-07-12)
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