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Amyotrophic Lateral Sclerosis
Motor neuron disease examined, role of truncated SOD1 clarified
July 12th, 2005
Recent research from Japan published in the journal Molecular Brain Research has reported on mouse motor neuron disease caused by truncated superoxide dismutase (SOD1) with or without C-terminal modification. "Mutation of Cu/Zn SOD I contributes to a portion of the cases of familial amyotrophic lateral sclerosis (FALS). We previously reported on a FALS family whose members had a mutant form of SOD1 characterized by a 2-base pair (bp) deletion at codon 126 of the SOD1 gene," wrote Y. Watanabe and colleagues, Tottori University. "To investigate the cellular consequences of this mutation, we produced transgenic mice that expressed normal and...
Source: Science Letter (2005-07-12)
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