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Acetylcholine Receptors
Thalamocortical synapses studied, hypocretin and nicotine responses defined
July 12th, 2005
According to recent research from the United States, hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex. "Thalamic projections to prefrontal cortex are important for executive aspects of attention. Using two-photon imaging in prefrontal brain slices, we show that nicotine and the wakefulness neuropeptide hypocretin (orexin) excite the same identified synapses of the thalamocortical arousal pathway within the prefrontal cortex," wrote E.K. Lambe and colleagues, Connecticut Mental Health Center. "Although it is known that attention can be improved when nicotine is infused directly into the midlayer of the prefrontal...
Source: Science Letter (2005-07-12)
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