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Actin
MARCKS analyzed, folding and actin inaccessibility revealed
July 12th, 2005
According to recently published research from the United States, myristoylated alanine-rich C kinase substrate (MARCKS) is a natively unfolded protein with an inaccessible actin-binding site. "MARCKS is an unfolded protein that contains well characterized actin-binding sites within the phosphorylation site domain (PSD), yet paradoxically, we now find that intact MARCKS does not bind to actin. Intact MARCKS also does not bind as well to calmodulin as does the PSD alone," wrote H. Tapp and colleagues, University of Florida. "Myristoylation at the N terminus alters how calmodulin binds to MARCKS, implying that, despite its unfolded state, the distant N...
Source: Science Letter (2005-07-12)
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