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Acute Myeloid Leukemia
Poor prognosis in pediatric acute myeloid leukemia linked to KIT mutations
April 21st, 2006
Poor prognosis in pediatric acute myeloid leukemia (AML) was linked to KIT mutations, and not FLT3 internal tandem duplication. According to recent research published in the journal Blood, "Patients with t(8;21) AML are considered to have a good prognosis; however, approximately 50% of them relapse. The genetic alterations associated with a poor outcome in t(8;21) AML remain unknown." "Recently, aberrations of receptor tyrosine kinases (RTKs) were frequently found in patients with AML," explained A. Shimada and colleagues, Gunma Children's Medical Center. "However, the prevalence and prognostic impact of RTK aberrations in pediatric t(8;21)...
Source: Science Letter (2006-04-21)
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