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Allergy & Immunology
An immunoadjuvant chaperone induces signals upon dendritic cell interaction
April 21st, 2006
According to a study from the United States, an immunoadjuvant chaperone induces signals upon dendritic cell (DC) interaction. "When chaperoning tumor antigens, glucose-regulated protein 170 (GRP170) is capable of inducing effective antitumour immune responses. In the present study, we determined whether such immunoadjuvant properties of GRP170 also involve the ability to induce 'danger signals' through interaction with APC," wrote M.H. Manjili and colleagues, Virginia Commonwealth University. "We prepared recombinant GRP170 in the baculovirus expression system with low endotoxin concentration at which LPS did not have any effect on DCs. We showed...
Source: Science Letter (2006-04-21)
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