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Allergy & Immunology
Mite allergen proform glycosylation decelerates the speed of maturation
April 21st, 2006
According to a study from Japan, mite allergen proform glycosylation decelerates the speed of maturation. "The efficient manufacture of recombinant Der p 1 and Der f 1 has been an important bottleneck in the study of house dust mite allergies and the development of applications for allergen engineering. While Der f 1 has only one N-glycosylation motif in the mature sequence, Der p 1 has two motifs, one in the prosequence and the other in the mature sequence. "To test whether inefficient maturation of a recombinant Pro-Der p 1 versus Pro-Der f 1 is due to N-glycosylation, the maturation speed of N-glycosylation motif mutants was compared," wrote T....
Source: Science Letter (2006-04-21)
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