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Allergy & Immunology
Study indicates how to re-induce tolerance in allergic contact dermatitis
April 21st, 2006
A new study indicates how to re-induce tolerance in allergic contact dermatitis. According to recent research from France, "Allergic contact dermatitis (ACD) is a skin inflammatory disease mediated by activation of CD8(+) cytotoxic T cells specific for haptens in contact with the skin. CD4(+) T cells behave as both regulatory and tolerogenic cells since they down-regulate the skin inflammation in patients with ACD (regulation) and prevent the development of eczema (tolerance) in normal individuals." "Thus, ACD corresponds to a breakdown of immune tolerance to haptens in contact with the skin. Several regulatory CD4(+) T cell subsets (Treg),...
Source: Science Letter (2006-04-21)
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