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Ampullary Cancer
Loss of expression of E-cadherin and beta-catenin linked to poor prognosis in ampullary cancer
April 21st, 2006
Loss of expression of E-cadherin and beta-catenin could be linked to poor prognosis in ampullary cancer. According to recent research from South Korea, "Ampullary carcinoma is uncommon but provides a good model for adenoma-carcinoma sequence. During the adenoma-carcinoma transition, the tumor cells should acquire the ability to invade." "The E-cadherin-catenin complex connects the adjacent epithelial cells at the zona adherens, and this adhesion interferes with the tumor cell invasion," explained S. Park and colleagues, Seoul National University. "One hundred and eleven cases of ampullary carcinoma were investigated with E-cadherin and beta-catenin...
Source: Science Letter (2006-04-21)
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