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Analgesia
Na+ channel analgesics compared in rat sensory neurons and Nav1.2 channels
April 21st, 2006
Recent research from Germany has reported on the comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels. "Na+ channel blockers are highly effective analgesics. Among the neuronal Na+ channel subtypes, Nav 1.8 is discussed to be of importance for certain pain states, and Nav 1.8-preferring Na+ channel blockers; should be able to relief pain without causing severe effects (due to the restricted expression of this channel type). "In this study," wrote T. Weiser and colleagues, Boehringer Ingelheim Pharma GmbH &...
Source: Science Letter (2006-04-21)
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