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Anthrax Pathogenesis
Macrophages play more dominant role than neutrophils in early host defense against anthrax
April 21st, 2006
Macrophages play a more dominant role than neutrophils in early host defense against Bacillus anthracis spores. According to a study from the United States, "The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We investigated the roles that macrophages and neutrophils play in the progression of infection by B. anthracis in a mouse model." "Mice were treated with a macrophage depletion agent (liposome-encapsulated clodronate) or with a neutrophil depletion agent (cyclophosphamide or the rat antimouse granulocyte monoclonal antibody...
Source: Science Letter (2006-04-21)
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