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Apoptosis
Neuronal apoptosis involves Bid cleavage and translocation to mitochondria
April 21st, 2006
Recent research published in the Journal of Biological Chemistry has chronicled the real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis. "Bcl-2 homology domain (BH) 3-only proteins couple stress signals to evolutionarily conserved mitochondrial apoptotic pathways. Caspase 8-mediated cleavage of the BH3-only protein Bid into a truncated protein (tBid) and subsequent translocation of tBid to mitochondria has been implicated in death receptor signaling. "We utilized a recombinant fluorescence resonance energy transfer (FRET) Bid probe to determine the kinetics of...
Source: Science Letter (2006-04-21)
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