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Apoptosis
p73 overexpression enhanced cisplatin-induced apoptosis in HeLa cells
April 21st, 2006
p73 overexpression could enhance cis-diamminedichloroplatinum II (cisplatin)-induced apoptosis in HeLa cells. According to a recent report, researchers in South Korea conducted a study "to examine a possible synergistic role for p73 and cisplatin in HeLa cells with a nonfunctional p53 protein, we established stable HeLa/p73 clones using a tetracycline inducible eukaryotic expression vector. The HeLa/p73 clones were not characterized by changes in growth or morphology." "Cell death analysis, however, indicated a greater sensitivity to cisplatin in the p73-overexpressed HeLa cells than determined for the non-induced HeLa cells," explained K.C. Kim and...
Source: Science Letter (2006-04-21)
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