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Arthritis
IL-18 redundancy observed in antigen-induced arthritis joint inflammation
April 21st, 2006
According to recent research published in the journal Immunology and Cell Biology, interlukin-18 (IL-18) is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis. "IL-18 is an important cofactor in Th1 immune responses and it has additional roles in inflammation. Recent reports suggest the contribution of IL-18 to immune responses may vary between mouse strains and immune contexts," wrote L.L. Santos and colleagues, Monash Medical Center. "We investigated the contribution of IL-18 to T-cell activation and joint inflammation in Ag-induced arthritis (AIA) in C57Bl/6 mice. AIA and cutaneous delayed-type hypersensitivity (DTH) reactions...
Source: Science Letter (2006-04-21)
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