Published in Sex Weekly Plus, October 26th, 1998
Phosphodiesterases play an important physiological role by regulating the intracellular levels of cyclic nucleotides.
Park et al. investigated the kinetic parameters of inhibition of phosphodiesterase (PDE) type 5 (EC 126.96.36.199, 3',5'-cyclic GMP phosphodiesterase) by a novel, high-affinity, selective PDE type 5 inhibitor, sildenafil, in intact cells and in soluble extracts of human clitoral corpus cavernosum smooth muscle cells ("Sildenafil Inhibits Phosphodiesterase Type 5 in Human...
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