Mechanisms

Sildenafil in Clitoral Corpus Cavernosum Smooth Muscle Cells

Published in Sex Weekly Plus, October 26th, 1998

Human clitoral corpus cavernosum smooth muscle tone may be regulated by the synthesis and release of nitric oxide and this pathway is dependent on PDE type 5 activity.

Phosphodiesterases play an important physiological role by regulating the intracellular levels of cyclic nucleotides.

Park et al. investigated the kinetic parameters of inhibition of phosphodiesterase (PDE) type 5 (EC 3.1.4.35, 3',5'-cyclic GMP phosphodiesterase) by a novel, high-affinity, selective PDE type 5 inhibitor, sildenafil, in intact cells and in soluble extracts of human clitoral corpus cavernosum smooth muscle cells ("Sildenafil Inhibits Phosphodiesterase Type 5 in Human...

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Source: Sex Weekly Plus (1998-10-26)

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